SCHEMBL932359

SCHEMBL932359

COc1ccc(C(C)CN)c(OC)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 3/20 0.56
ADRA2A P08913 2/20 0.56
HTR2A P28223 2/20 0.55
HTR2C P28335 1/20 0.55
HTR2B P41595 1/20 0.55
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
ALDH1A1 P00352 3/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 2/20 0.46
TAAR1 Q96RJ0 1/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
MAPK1 P28482 1/20 0.45
BLM P54132 1/20 0.45
APLNR P35414 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11424531 0.86 ADRA1A (0.70) ADRA1AADRA2AHTR2AHTR2CHTR2B
SCHEMBL10172021 0.84 CA12 (0.50) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL11077851 0.84 ADRA1A (0.57) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL7002647 0.84 ADRA1A (0.57) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL12606793 0.84 CA12 (0.50) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL11437277 0.84 CA12 (0.50) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL18995540 0.82 CA12 (0.48) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL11658602 0.82 ADRA1A (0.56) ADRA1AADRA2AHTR2ACA12CA1
SCHEMBL7153263 0.82 ADRA1A (0.75) ADRA1AADRA2ACA12CA1CA2
SCHEMBL14655824 0.81 ADRA1A (0.54) ADRA1AADRA2AHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017066488-A1 TREATING PAIN USING A COMPOSITION COMPRISING AN OPIOID AND AN ANTIEMETIC CHARLESTON LABORATORIES, INC. (US) 2017-04-20 WO disclosed
EP-3129028-A1 PHARMACEUTICAL COMPOSITIONS Charleston Laboratories, Inc. (US) 2017-02-15 EP disclosed
WO-2015157738-A1 PHARMACEUTICAL COMPOSITIONS CHARLESTON LABORATORIES, INC. (US) 2015-10-15 WO disclosed
EP-2451274-A1 PHARMACEUTICAL COMPOSITIONS Charleston Laboratories Inc. (US) 2012-05-16 EP disclosed
WO-2011006012-A1 PHARMACEUTICAL COMPOSITIONS CHARLESTON LABORATORIES INC. (US) 2011-01-13 WO disclosed