Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11077851 | 0.85 | ADRA1A (0.57) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL11658602 | 0.84 | ADRA1A (0.56) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL932359 | 0.84 | ADRA1A (0.56) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL7153263 | 0.84 | ADRA1A (0.75) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL14655824 | 0.82 | ADRA1A (0.54) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL11078217 | 0.80 | ADRA1A (0.49) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL6993305 | 0.80 | ADRA2A (0.40) | ADRA1AADRA2AHTR2A | |
| SCHEMBL7000257 | 0.80 | ADRA1A (0.47) | ADRA1AADRA2ATAAR1BCHETYR | |
| SCHEMBL8784289 | 0.79 | LDHA (0.50) | ADRA1AADRA2ACA12CA1CA2 | |
| SCHEMBL9055995 | 0.79 | CA12 (0.47) | ADRA1AADRA2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |