Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465989 | 0.83 | CYP3A4 (0.64) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL9324238 | 0.81 | LTB4R (0.68) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8461403 | 0.78 | MAOB (0.52) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL9326054 | 0.78 | LTB4R (0.69) | LTB4R | |
| SCHEMBL9326055 | 0.78 | LTB4R (0.69) | LTB4R | |
| SCHEMBL9326052 | 0.78 | LTB4R (0.69) | LTB4R | |
| SCHEMBL8462441 | 0.76 | CYP19A1 (0.65) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8466153 | 0.76 | LTB4R (0.67) | LTB4R | |
| SCHEMBL9326026 | 0.75 | LTB4R (0.65) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL23882635 | 0.74 | GRM5 (0.53) | MAOBMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298512-A | Substituted chromans and their use in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0391625-B1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1990012010-A1 | SUBSTITUTED CHROMANS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391625-A1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |