Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR5A1 | Q13285 | 1/20 | 0.63 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | RARB | P10826 | 3/20 | 0.53 |
| ▸ | PLK1 | P53350 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492191 | 0.92 | PTPN11 (0.64) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL7820620 | 0.92 | PTPN11 (0.64) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL9325744 | 0.91 | NR5A1 (0.61) | NR5A1PLA2G4BTP53TSHRPTPN11 | |
| SCHEMBL9324047 | 0.88 | PTPN11 (0.58) | PLA2G4BTP53TSHRPTPN11PLK1 | |
| SCHEMBL4369286 | 0.88 | PTPN11 (0.56) | NR5A1PLA2G4BTP53TSHRPTPN11 | |
| SCHEMBL1750042 | 0.87 | PTPN11 (0.57) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL20919872 | 0.85 | PTPN11 (0.57) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL12432167 | 0.85 | THRA (0.67) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL4518420 | 0.85 | PTPN11 (0.61) | PLA2G4BTP53TSHRPTPN11RARB | |
| SCHEMBL11237589 | 0.85 | THRA (0.67) | PLA2G4BTP53TSHRPTPN11RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |