Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932204 | 0.86 | BACE1 (0.67) | BACE1BACE2KCNH2 | |
| SCHEMBL932184 | 0.84 | BACE1 (0.48) | BACE1BACE2KCNH2CTSD | |
| SCHEMBL932682 | 0.84 | BACE1 (0.53) | BACE1BACE2KCNH2CTSD | |
| SCHEMBL932646 | 0.79 | BACE1 (0.46) | BACE1KCNH2CTSD | |
| SCHEMBL932202 | 0.78 | BACE1 (0.34) | BACE1BACE2CTSD | |
| SCHEMBL932215 | 0.76 | BACE1 (0.41) | BACE1BACE2KCNH2CTSD | |
| SCHEMBL931694 | 0.75 | BACE1 (0.73) | BACE1BACE2KCNH2CTSD | |
| SCHEMBL947178 | 0.74 | CTSD (0.37) | BACE1BACE2CTSD | |
| SCHEMBL932503 | 0.73 | BACE1 (0.67) | BACE1BACE2KCNH2CTSD | |
| SCHEMBL932175 | 0.73 | BACE1 (0.51) | BACE1BACE2KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |