Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 7/20 | 0.52 |
| ▸ | PKLR | P30613 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932284 | 0.89 | PKM (0.61) | KMT2AALDH1A1PKMPKLRMEN1 | |
| SCHEMBL933278 | 0.80 | KMT2A (0.54) | KMT2AALDH1A1MAPTGPR183PKM | |
| SCHEMBL932255 | 0.76 | MCOLN3 (0.59) | KMT2AALDH1A1PKMPKLRMEN1 | |
| SCHEMBL18134604 | 0.74 | MCOLN3 (0.83) | KMT2APKMPKLRMEN1LMNA | |
| SCHEMBL932192 | 0.74 | PKM (0.52) | KMT2AALDH1A1MAPTGPR183PKM | |
| SCHEMBL932197 | 0.73 | PKM (0.59) | KMT2AALDH1A1PKMPKLRMEN1 | |
| SCHEMBL9951143 | 0.72 | PKM (0.76) | KMT2AALDH1A1MAPTGPR183PKM | |
| SCHEMBL5734563 | 0.72 | MCOLN3 (0.69) | KMT2APKMPKLRMEN1LMNA | |
| SCHEMBL932971 | 0.72 | MCOLN3 (0.58) | KMT2AALDH1A1PKMPKLRMEN1 | |
| SCHEMBL932955 | 0.71 | KMT2A (0.54) | KMT2AALDH1A1MAPTPKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448581-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002816-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |