Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225351 | 0.88 | PTPN1 (0.51) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12696322 | 0.86 | PTPN1 (0.50) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2442541 | 0.86 | PPARA (0.53) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL656934 | 0.84 | PSEN1 (0.48) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL198467 | 0.84 | PTPN1 (0.60) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1586865 | 0.84 | LMNA (0.57) | PTPN1POLBGAACYP2C19 | |
| SCHEMBL5702452 | 0.84 | PSEN1 (0.49) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7643204 | 0.83 | ACHE (0.52) | PTPN1TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL7201519 | 0.83 | TAAR1 (0.55) | PTPN1TAAR1MAOBCYP2C19 | |
| SCHEMBL8752337 | 0.83 | CYP1A2 (0.52) | PTPN1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356894-A | Adenosine antagonists | SYNGENTA LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| US-5270311-A | [1,2,4]-Triazolo[1,5-a]and pyrazolo[2,3-a][1,3,5]triazine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| EP-0459702-A1 | Azole Derivatives | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0277917-A2 | Certain adenosine 5'-carboxamide derivatives | CIBA-GEIGY AG (CH) | 1988-08-10 | — | — | EP | disclosed |