Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TAS2R46 | P59540 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326508 | 1.00 | ALOX15 (0.51) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL9325972 | 1.00 | ALOX15 (0.51) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL5074026 | 0.89 | ALOX15 (0.49) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL15083628 | 0.82 | ALOX15 (0.43) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL7226012 | 0.80 | ALOX15 (0.40) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL9325970 | 0.79 | CHRM2 (0.36) | ALOX15TSHRUSP2CYP3A4CYP19A1 | |
| SCHEMBL9326863 | 0.79 | CHRM2 (0.36) | ALOX15TSHRUSP2CYP3A4CYP19A1 | |
| SCHEMBL9326867 | 0.79 | CHRM2 (0.36) | ALOX15TSHRUSP2CYP3A4CYP19A1 | |
| SCHEMBL7231451 | 0.77 | ALOX15 (0.38) | ALOX15TSHRUSP2CYP3A4HSD11B1 | |
| SCHEMBL9325971 | 0.77 | NAAA (0.39) | ALOX15TSHRCYP19A1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112805006-B | PRMT5 inhibitors | 默沙东有限责任公司 | 2024-09-24 | — | — | CN | disclosed |
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3833355-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020033288-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
| EP-0414453-B1 | Optically active cyclopentenols and process for preparing the same | CHISSO CORP (JP) | 1994-02-23 | — | — | EP | disclosed |
| US-5107039-A | Intermediates for asymmetric synthesis of steroids and alkaloids | CHISSO CORPORATION (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0414453-A1 | Optically active cyclopentenols and process for preparing the same | Chisso Corporation (JP) | 1991-02-27 | — | — | EP | disclosed |