Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326134 | 0.91 | PTGS2 (0.57) | PDE4BPTGS2PDE4APDE4CPDE4D | |
| SCHEMBL6919617 | 0.85 | PDE4A (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL26103743 | 0.84 | KDM4E (0.46) | PDE4BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3961649 | 0.80 | ALDH1A1 (0.57) | PTGS2KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL7364691 | 0.79 | PDE4A (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL11188161 | 0.78 | CYP19A1 (0.42) | PDE4BPTGS2PDE4APDE4CPDE4D | |
| SCHEMBL678459 | 0.77 | NCOA1 (0.62) | ALDH1A1LMNA | |
| SCHEMBL7337614 | 0.76 | PDE4A (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5793895 | 0.76 | PTGS2 (0.42) | PTGS2MAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL22213562 | 0.75 | EGFR (0.45) | ALDH1A1MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523138-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-01-20 | — | — | EP | claimed |
| WO-1991015451-A1 | NOVEL DERIVATIVES OF PHENYL-CYCLOALKANES AND -CYCLOALKENES | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1991-10-17 | — | — | WO | claimed |
| US-5362915-A | Inhibitors of enzymes/hydrolases; antiallergens, antiinflammatory agents | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-11-08 | — | — | US | disclosed |