Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.36 |
| ▸ | MMP3 | P08254 | 13/20 | 0.36 |
| ▸ | MMP1 | P03956 | 10/20 | 0.36 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9745592 | 0.86 | HDAC8 (0.45) | MMP3MMP1MMP9 | |
| SCHEMBL7303252 | 0.82 | ALDH2 (0.37) | — | |
| SCHEMBL9326302 | 0.82 | POLB (0.52) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL9326295 | 0.82 | POLB (0.52) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL9328354 | 0.80 | TACR3 (0.37) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL9671711 | 0.79 | EPHX1 (0.35) | MMP2MMP3MMP1MMP9MMP14 | |
| SCHEMBL7303995 | 0.78 | CA2 (0.40) | — | |
| SCHEMBL7301168 | 0.78 | CA2 (0.40) | — | |
| SCHEMBL9671527 | 0.78 | CA2 (0.40) | — | |
| SCHEMBL868387 | 0.77 | POLB (0.48) | MMP2MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5089485-A | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| EP-0369811-A2 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1990-05-23 | — | — | EP | disclosed |