Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985038 | 0.88 | SMN1; SMN2 (0.43) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL9326264 | 0.86 | MMP2 (0.36) | MMP1MMP3MMP9 | |
| SCHEMBL9326302 | 0.85 | POLB (0.52) | ALDH1A1MEN1MAPTKMT2AMMP1 | |
| SCHEMBL9326295 | 0.85 | POLB (0.52) | ALDH1A1MEN1MAPTKMT2AMMP1 | |
| SCHEMBL9745110 | 0.82 | HDAC8 (0.40) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL7303252 | 0.76 | ALDH2 (0.37) | MAPK1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL9766947 | 0.72 | GPR84 (0.42) | MAPTMMP9 | |
| SCHEMBL7301168 | 0.72 | CA2 (0.40) | ALDH1A1SMN1; SMN2MEN1MAPK1KMT2A | |
| SCHEMBL9671527 | 0.72 | CA2 (0.40) | ALDH1A1SMN1; SMN2MEN1MAPK1KMT2A | |
| SCHEMBL7303995 | 0.72 | CA2 (0.40) | ALDH1A1SMN1; SMN2MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089485-A | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0369811-A2 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1990-05-23 | — | — | EP | disclosed |