Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326876 | 0.94 | SIGMAR1 (0.57) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9326978 | 0.87 | SIGMAR1 (0.57) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9326574 | 0.87 | SIGMAR1 (0.57) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9327736 | 0.86 | SIGMAR1 (0.56) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9326452 | 0.84 | SIGMAR1 (0.61) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9325549 | 0.84 | SIGMAR1 (0.57) | SIGMAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8814712 | 0.84 | SLC6A4 (0.78) | SLC6A4HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL9326403 | 0.84 | SIGMAR1 (0.57) | SIGMAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9327638 | 0.83 | SIGMAR1 (0.60) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B | |
| SCHEMBL9325726 | 0.82 | SIGMAR1 (0.55) | SIGMAR1SLC6A4HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288749-A | Treating central nervous system or cardiovascular disorders | ABBOTT LABORATORIES (US) | 1994-02-22 | — | — | US | disclosed |