Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327169 | 1.00 | CYP19A1 (0.34) | CYP19A1LMNACYP3A4CYP2C9MAPK1 | |
| SCHEMBL14441019 | 0.81 | CYP19A1 (0.36) | CYP19A1 | |
| SCHEMBL14470547 | 0.75 | CYP19A1 (0.33) | CYP19A1 | |
| SCHEMBL1136296 | 0.74 | SMN1; SMN2 (0.35) | CYP19A1LMNA | |
| SCHEMBL1136293 | 0.74 | SMN1; SMN2 (0.35) | CYP19A1LMNA | |
| SCHEMBL9323827 | 0.72 | — | — | |
| SCHEMBL9637397 | 0.72 | — | — | |
| SCHEMBL10704819 | 0.72 | CYP19A1 (0.39) | CYP19A1 | |
| SCHEMBL9186852 | 0.71 | GABRP (0.33) | — | |
| SCHEMBL9254729 | 0.71 | GABRP (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357009-B1 | Method of resolution of hydroxy-cyclopentenones using a lipase and transacylation agents | SEARLE & CO (US) | 1994-03-02 | — | — | EP | disclosed |
| US-5106750-A | Enzymatic resolution of hydroxycyclopentenones using lipase | G. D. SEARLE & CO. (US) | 1992-04-21 | — | — | US | disclosed |