Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 7/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9810864 | 1.00 | MAPT (0.43) | MAPTCYP3A4ALDH1A1TTRDPP4 | |
| SCHEMBL9328360 | 0.83 | MAPT (0.44) | MAPTCYP3A4ALDH1A1VCAM1HPN | |
| SCHEMBL9328370 | 0.83 | MAPT (0.44) | MAPTCYP3A4ALDH1A1VCAM1HPN | |
| SCHEMBL9550806 | 0.75 | MAPT (0.50) | MAPTCYP3A4ALDH1A1VCAM1HPN | |
| SCHEMBL6910749 | 0.74 | CYP3A4 (0.61) | CYP3A4TTRDPP4NR1I2HMGCR | |
| SCHEMBL6910750 | 0.74 | CYP3A4 (0.61) | CYP3A4TTRDPP4NR1I2HMGCR | |
| SCHEMBL27904472 | 0.73 | CYP3A4 (0.59) | CYP3A4TTRDPP4NR1I2HMGCR | |
| SCHEMBL646924 | 0.72 | ALOX15 (0.63) | MAPTCYP3A4ALDH1A1VCAM1HPN | |
| SCHEMBL9328270 | 0.72 | MAPT (0.41) | MAPTCYP3A4ALDH1A1VCAM1HPN | |
| SCHEMBL9328259 | 0.72 | MAPT (0.41) | MAPTCYP3A4ALDH1A1VCAM1HPN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | claimed |
| EP-0293900-A2 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | claimed |
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | disclosed |