Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.42 |
| ▸ | GLRB | P48167 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 10/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9328370 | 1.00 | MAPT (0.44) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL9490152 | 0.85 | MAPT (0.46) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL9490139 | 0.85 | MAPT (0.46) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL9328087 | 0.83 | MAPT (0.43) | MAPTHPNALOX15SIRT5VCAM1 | |
| SCHEMBL9810864 | 0.83 | MAPT (0.43) | MAPTHPNALOX15SIRT5VCAM1 | |
| SCHEMBL9550806 | 0.80 | MAPT (0.50) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL9490898 | 0.79 | MAPT (0.42) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL9490895 | 0.79 | MAPT (0.42) | MAPTHPNALOX15SIRT5GLRA3 | |
| SCHEMBL646924 | 0.78 | ALOX15 (0.63) | MAPTHPNALOX15SIRT5GABBR2 | |
| SCHEMBL8309788 | 0.77 | VCAM1 (0.55) | MAPTHPNALOX15SIRT5GLRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |