Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 8/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.40 |
| ▸ | GLRB | P48167 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326943 | 0.85 | GLRA3 (0.46) | VCAM1PTGS1GAACA2CA1 | |
| SCHEMBL10357684 | 0.76 | CA2 (0.44) | GAACA2CA1ALDH1A1TDP1 | |
| SCHEMBL7698176 | 0.76 | HDAC3 (0.47) | GAAALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10357467 | 0.73 | GPR55 (0.39) | VCAM1GAACA2CA1ALDH1A1 | |
| SCHEMBL490767 | 0.73 | GAA (0.67) | VCAM1PTGS1GAACA2CA1 | |
| SCHEMBL10357689 | 0.72 | GLRA3 (0.37) | VCAM1GAACA2CA1ALDH1A1 | |
| Methane SCHEMBL9226524 | 0.72 | GAA (0.65) | VCAM1PTGS1GAACA2CA1 | |
| SCHEMBL7647695 | 0.72 | GAA (0.65) | VCAM1PTGS1GAACA2CA1 | |
| SCHEMBL9774992 | 0.72 | PTGS1 (0.57) | VCAM1PTGS1GAACA2CA1 | |
| SCHEMBL6858351 | 0.71 | HSP90AB1 (0.59) | VCAM1PTGS1GAACA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | claimed |
| EP-0293900-A2 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | claimed |
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | disclosed |
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0293900-A2 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |