SCHEMBL9328476

SCHEMBL9328476

Cc1ccc(C(C)(OP(O)Cl)c2ccc(C)cc2C(C)c2ccccc2)c(C(C)c2ccccc2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 1/20 0.36
LMNA P02545 2/20 0.34
MAPT P10636 2/20 0.34
CHRM2 P08172 2/20 0.34
CHRM5 P08912 2/20 0.34
CHRM1 P11229 2/20 0.34
CHRM3 P20309 2/20 0.34
HRH1 P35367 2/20 0.34
ESR1 P03372 1/20 0.34
CHRM4 P08173 1/20 0.34
KCNE1 P15382 1/20 0.34
PTGS1 P23219 1/20 0.34
HRH2 P25021 1/20 0.34
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
ADRA1A P35348 1/20 0.34
OPRK1 P41145 1/20 0.34
KCNQ1 P51787 1/20 0.34
KCNH2 Q12809 1/20 0.34
CACNA1C Q13936 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10442706 0.77 TYR (0.39) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL9328289 0.74 SMN1; SMN2 (0.37) TYRMAPTPTGS1HTT
SCHEMBL9328465 0.72 TYR (0.40) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL10442707 0.72 TYR (0.37) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL29509825 0.69 CHRM1 (0.57) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL222362 0.69 CHRM1 (0.57) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL7952148 0.69 TYR (0.39) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL444327 0.68 TYR (0.46) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL29486495 0.68 TYR (0.46) TYRLMNAMAPTCHRM2CHRM5
SCHEMBL11261908 0.68 CYP1A2 (0.37) TYRLMNAMAPTCHRM2CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0357048-B1 Process for transhalogenating a halophosphorus compound with hydrogen fluoride ALBEMARLE CORP (US) 1994-09-28 EP disclosed
EP-0358985-B1 Method of transhalogenating a halophosphorus compound with fluoride ETHYL CORP (US) 1994-03-16 EP disclosed
EP-0312790-B1 Process for transhalogenating a halophosphorus compound with fluoride ETHYL CORP (US) 1993-11-18 EP disclosed
US-5136075-A Process for transhalogenating a halophosphorus compound with fluoride ETHYL CORPORATION (US) 1992-08-04 US disclosed
US-5061818-A Fluorination with metal or ammonium fluoride in presence of pyridine halide salt ETHYL CORPORATION (US) 1991-10-29 US disclosed
US-5049691-A Process for transhalogenating a halophosphorous compound with anhydrous hydrogen fluoride ETHYL CORPORATION (US) 1991-09-17 US disclosed
US-4929745-A Transhalogenation of halophosphorus compounds EHTYL CORPORATION (US) 1990-05-29 US disclosed
US-4910324-A Using a metal or ammonium fluoride ETHYL CORPORATION (US) 1990-03-20 US disclosed
EP-0357048-A2 Process for transhalogenating a halophosphorus compound with hydrogen fluoride ALBEMARLE CORPORATION (US) 1990-03-07 EP disclosed
EP-0353598-A2 Transhalogenation of halophosphorus compounds ETHYL CORPORATION (US) 1990-02-07 EP disclosed
EP-0312790-A2 Process for transhalogenating a halophosphorus compound with fluoride ETHYL CORPORATION (US) 1989-04-26 EP disclosed