SCHEMBL9328615

SCHEMBL9328615

CC1CC(C)(C)c2cc(C#C[Si](C)(C)C)ccc2S1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RARA P10276 2/20 0.35
RARB P10826 2/20 0.35
RARG P13631 2/20 0.35
CYP3A4 P08684 2/20 0.33
CYP26A1 O43174 1/20 0.33
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9330444 0.80 CTSD (0.33)
SCHEMBL9329536 0.77 RARB (0.57) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9028813 0.76 RARB (0.38) RARARARBRARGCYP3A4CYP26A1
SCHEMBL8558172 0.75 RARB (0.40) RARARARBRARGCYP3A4CYP26A1
SCHEMBL4373673 0.75 RARB (0.58) RARARARBRARGCYP3A4CYP26A1
SCHEMBL4509176 0.72 GABRA5 (0.34) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9331449 0.72 RARB (0.55) RARARARBRARGCYP3A4CYP26A1
SCHEMBL6472676 0.71 RARB (0.35) RARARARBRARGCYP3A4CYP26A1
SCHEMBL3300659 0.70 RARB (0.55) RARARARBRARGCYP3A4CYP26A1
SCHEMBL9273777 0.68 RARB (0.36) RARARARBRARGCYP3A4CYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5278318-A Acetylation under Friedel Crafts condition ALLERGAN, INC. (US) 1994-01-11 US disclosed
EP-0553156-A4 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY 1993-11-18 EP disclosed
EP-0555235-A4 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY 1993-11-10 EP disclosed
EP-0555235-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-18 EP disclosed
EP-0553156-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-04 EP disclosed
US-5162546-A ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-11-10 US disclosed
WO-1992006084-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed
WO-1992006092-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed