Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330030 | 0.90 | ALDH1A1 (0.51) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9328926 | 0.88 | CYP1A2 (0.58) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9330135 | 0.84 | CYP1A2 (0.58) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9331009 | 0.84 | AURKA (0.51) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9331022 | 0.84 | CYP1A2 (0.56) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9328609 | 0.83 | AURKA (0.43) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9327573 | 0.80 | GLA (0.46) | AHRCYP1A2CYP1A1CYP1B1PRKDC | |
| SCHEMBL13125653 | 0.77 | HSD17B10 (0.47) | AURKADAPK3MAP4K4RETIGF1R | |
| SCHEMBL9328479 | 0.72 | CYP2D6 (0.44) | AHRCYP1A2CYP1A1CYP1B1PRKDC | |
| SCHEMBL4484990 | 0.72 | AURKA (0.48) | AURKADAPK3MAP4K4RETIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454728-B1 | FLUORINATED FLAVONE ACETIC ACID | UPJOHN CO (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5238954-A | Antitumor agents | THE UPJOHN COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0454728-A1 | FLUORINATED FLAVONE ACETIC ACID. | UPJOHN CO (US) | 1991-11-06 | — | — | EP | disclosed |
| WO-1990008143-A1 | FLUORINATED FLAVONE ACETIC ACID | THE UPJOHN COMPANY (US) | 1990-07-26 | — | — | WO | disclosed |