SCHEMBL9327573

SCHEMBL9327573

O=C(O)Cc1cccc2c(=O)cc(-c3c(F)cccc3F)oc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.46
STING1 Q86WV6 1/20 0.46
CYP2D6 P10635 3/20 0.46
AHR P35869 1/20 0.45
CYP1A2 P05177 5/20 0.45
CYP3A4 P08684 2/20 0.45
CYP2C19 P33261 2/20 0.45
STAT6 P42226 1/20 0.45
CYP1A1 P04798 4/20 0.42
CYP1B1 Q16678 4/20 0.42
PRKDC P78527 3/20 0.42
TDP1 Q9NUW8 1/20 0.40
CXCL8 P10145 2/20 0.39
NPC1 O15118 2/20 0.39
ALDH1A1 P00352 2/20 0.39
LMNA P02545 1/20 0.39
OPRD1 P41143 1/20 0.39
OPRK1 P41145 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CYSLTR1 Q9Y271 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9328479 0.93 CYP2D6 (0.44) GLASTING1CYP2D6AHRCYP1A2
SCHEMBL9327921 0.90 CYP2D6 (0.44) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL9328862 0.90 ALDH1A1 (0.51) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL9330744 0.88 CYP1A2 (0.58) GLASTING1CYP2D6AHRCYP1A2
SCHEMBL9329003 0.86 CYP1A2 (0.48) GLASTING1CYP2D6AHRCYP1A2
SCHEMBL9328729 0.85 CYP2D6 (0.49) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL9327546 0.84 CYP1A2 (0.58) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL9327900 0.84 CYP1A2 (0.56) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL9327677 0.84 CYP2D6 (0.53) GLASTING1CYP2D6CYP1A2CYP3A4
SCHEMBL12835292 0.83 CYP2D6 (0.51) GLASTING1CYP2D6CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP claimed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US claimed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP claimed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO claimed
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP disclosed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US disclosed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP disclosed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO disclosed