Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136459 | 0.84 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2GABRA5GABRB2 | |
| SCHEMBL8136460 | 0.84 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2GABRA5GABRB2 | |
| SCHEMBL9367873 | 0.83 | MEN1 (0.41) | NPC1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL9143716 | 0.83 | MEN1 (0.41) | NPC1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL8316832 | 0.83 | MEN1 (0.51) | NPC1RAB9ASMN1; SMN2GABRA5GABRB2 | |
| SCHEMBL9329551 | 0.83 | MEN1 (0.41) | NPC1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL9331537 | 0.83 | MEN1 (0.41) | NPC1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL8316834 | 0.83 | MEN1 (0.51) | NPC1RAB9ASMN1; SMN2GABRA5GABRB2 | |
| SCHEMBL9143711 | 0.83 | MEN1 (0.41) | NPC1RAB9AGABRA5GABRB2HSD17B10 | |
| SCHEMBL9332012 | 0.83 | MEN1 (0.51) | NPC1RAB9ASMN1; SMN2GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225634-B1 | Antibacterial compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-04-06 | — | — | EP | disclosed |
| US-4839351-A | Antibacterial compounds, and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0229369-A2 | Cephalosporins, process for their preparation and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |
| EP-0225634-A2 | Antibacterial compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-06-16 | — | — | EP | disclosed |