Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 4/20 | 0.41 |
| ▸ | GABRD | O14764 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.41 |
| ▸ | GABRE | P78334 | 4/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropylamine SCHEMBL910225 | 0.84 | — | — | |
| SCHEMBL14601662 | 0.81 | SLC7A5 (0.53) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Fumaric Acid SCHEMBL28068205 | 0.81 | GABRP (0.59) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Bicarbonate SCHEMBL1833319 | 0.80 | — | — | |
| Bicarbonate SCHEMBL14244879 | 0.79 | ALDH1A1 (0.50) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Bicarbonate SCHEMBL6614831 | 0.79 | ALDH1A1 (0.50) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| SCHEMBL56276 | 0.78 | — | — | |
| SCHEMBL56475 | 0.78 | — | — | |
| SCHEMBL3609 | 0.78 | — | — | |
| Acetic Acid SCHEMBL6051117 | 0.77 | FFAR3 (0.54) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0387605-B1 | Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols | BAYER AG (DE) | 1994-03-30 | — | — | EP | disclosed |
| EP-0387605-A2 | Process for the stereoselective preparation of optically active S,S or R,R-beta-aminoalcohols | BAYER AG (DE) | 1990-09-19 | — | — | EP | disclosed |