Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.74 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696471 | 0.86 | — | — | |
| SCHEMBL29286885 | 0.86 | CRBN (1.00) | CRBNTAS2R38LMNABLMPMP22 | |
| Hydrochloric Acid SCHEMBL6044944 | 0.83 | — | — | |
| Diacetamide SCHEMBL8445431 | 0.83 | CRBN (0.53) | CRBNTAS2R38PAOXLMNABLM | |
| Formaldehyde SCHEMBL28223031 | 0.80 | — | — | |
| Diacetamide SCHEMBL27572032 | 0.78 | CRBN (0.48) | CRBNTAS2R38PAOXLMNABLM | |
| SCHEMBL27424245 | 0.76 | CRBN (0.78) | CRBNTAS2R38LMNABLMPMP22 | |
| Ethylenediamine SCHEMBL28107761 | 0.75 | CRBN (0.43) | CRBNLMNABLMPMP22MAPT | |
| Acetamide SCHEMBL2162710 | 0.73 | LMNA (0.67) | CRBNPAOXLMNABLMPMP22 | |
| Acetamide SCHEMBL8445429 | 0.73 | LMNA (0.67) | CRBNPAOXLMNABLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365421-B1 | Specific ligands for estrogenic and progestagenic steroidal hormone receptors, their use and synthesis intermediates | WALLONE REGION (BE) | 1994-03-23 | — | — | EP | disclosed |
| EP-0365421-A1 | Specific ligands for estrogenic and progestagenic steroidal hormone receptors, their use and synthesis intermediates | LA REGION WALLONNE (BE) | 1990-04-25 | — | — | EP | disclosed |