Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Acetamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.67 |
| ▸ | BLM | P54132 | 3/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.36 |
| ▸ | THPO | P40225 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL2162710 | 1.00 | LMNA (0.67) | LMNAALOX15BLMPMP22PAOX | |
| Acetic Acid SCHEMBL27960615 | 0.93 | LMNA (0.57) | LMNAALOX15BLMPMP22PAOX | |
| Acetone SCHEMBL29084624 | 0.87 | LMNA (0.55) | LMNAALOX15BLMPMP22PAOX | |
| Acetone SCHEMBL27390523 | 0.87 | — | — | |
| Acetic Acid SCHEMBL28164703 | 0.85 | FFAR3 (0.50) | LMNAALOX15BLMPMP22PAOX | |
| Acetamide SCHEMBL28229707 | 0.85 | — | — | |
| Acetamide SCHEMBL9542290 | 0.85 | LMNA (0.57) | LMNAALOX15BLMPMP22PAOX | |
| Acetamide SCHEMBL1058244 | 0.85 | LMNA (0.57) | LMNAALOX15BLMPMP22PAOX | |
| Acetamide SCHEMBL1060168 | 0.85 | — | — | |
| Acetamide SCHEMBL66201 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932655-A1 | FUEL COMPOSITIONS | Infineum Holdings BV (NL) | 1999-08-04 | — | — | EP | disclosed |
| US-5855630-A | MULTIPLE AMIDE POLYETHER ALCOHOL ADDITIVES | SHELL OIL COMPANY (US) | 1999-01-05 | — | — | US | disclosed |
| WO-1998016598-A1 | FUEL COMPOSITIONS | INFINEUM HOLDINGS BV (NL) | 1998-04-23 | — | — | WO | disclosed |