Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | IKBKB | O14920 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932931 | 1.00 | CYP1A2 (0.70) | CYP1A2IKBKBMEN1KMT2APIM1 | |
| Hydrochloric Acid SCHEMBL27967108 | 0.98 | CYP1A2 (0.68) | CYP1A2IKBKBMEN1KMT2APIM1 | |
| SCHEMBL11827285 | 0.82 | CYP1A2 (1.00) | CYP1A2PTGS2HSD11B1MAPK1CYP3A4 | |
| SCHEMBL11841447 | 0.82 | CYP1A2 (0.93) | CYP1A2HSD11B1MAPK1CYP2C9 | |
| SCHEMBL11827276 | 0.82 | CYP1A2 (1.00) | CYP1A2PTGS2HSD11B1MAPK1CYP3A4 | |
| SCHEMBL17899503 | 0.82 | CYP1A2 (1.00) | CYP1A2PTGS2HSD11B1MAPK1CYP3A4 | |
| SCHEMBL11841453 | 0.82 | CYP1A2 (0.93) | CYP1A2HSD11B1MAPK1CYP2C9 | |
| SCHEMBL13720053 | 0.79 | IKBKB (1.00) | CYP1A2IKBKBMEN1KMT2APIM1 | |
| SCHEMBL28205340 | 0.79 | CYP1A2 (0.45) | CYP1A2IKBKBMEN1KMT2APIM1 | |
| SCHEMBL31518760 | 0.78 | CYP1A2 (0.64) | CYP1A2IKBKBMEN1KMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102477012-B | Preparation and application of curcumin analogs capable of inhibiting activity of 11beta-hydroxysteroid dehydrogenase type II (11beta-HSD2) of human | UNIV JINAN | 2014-08-13 | — | — | CN | disclosed |
| US-20120316203-A1 | Compositions and Methods for Inhibition of Cancers | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-12-13 | — | — | US | disclosed |
| EP-2451273-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS | The Ohio State University Research Foundation (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005790-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316203-A1 | Compositions and Methods for Inhibition of Cancers | HCCS, GPX4, HMOX1 | CYP1A2 2155/4885IKBKB 2646/4885MEN1 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.