Sugi Predict

Sugi Predict / Compounds / SCHEMBL9329604

SCHEMBL9329604

SCHEMBL9329604

CCNc1ccncc1N

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ AOC1 P19801 6/20 0.56
▸ AOC3 Q16853 6/20 0.56
▸ GAA P10253 3/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MAPT P10636 1/20 0.42
▸ THRB P10828 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ GFER P55789 1/20 0.42
▸ PLEC Q15149 1/20 0.42
▸ GLA P06280 1/20 0.41
▸ MKNK1 Q9BUB5 1/20 0.39
▸ MKNK2 Q9HBH9 1/20 0.39
▸ LATS1 O95835 1/20 0.37
▸ LATS2 Q9NRM7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30703857 1.00 AOC1 (0.56) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL8241807 0.85 KDM4C (0.53) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL2268998 0.84 AOC1 (0.61) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL8252207 0.77 MAPT (0.43) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL30074192 0.77 — —
SCHEMBL2046959 0.77 — —
Pyridine SCHEMBL7022106 0.77 AOC1 (0.53) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL2551503 0.77 PTGER4 (0.49) AOC1AOC3GAAKDM4EALDH1A1
SCHEMBL8379440 0.76 AOC1 (0.51) AOC1AOC3KDM4EALDH1A1HPGD
SCHEMBL21782174 0.76 AOC1 (0.56) AOC1AOC3MKNK1MKNK2LATS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113348170-B Biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-12-22 — — CN disclosed
US-20230105212-A1 BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) 2023-04-06 — — US disclosed
EP-4086253-A1 BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Hansoh Biomedical Co., Ltd. (CN) 2022-11-09 — — EP disclosed
CN-113348170-A Biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2021-09-03 — — CN disclosed
WO-2021136354-A1 BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2021-07-08 — — WO disclosed
WO-2021136354-A1 BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2021-07-08 — — WO disclosed
EP-3486245-B1 2-AMINO-N-(PIPERIDIN-1-YL-PYRIDIN-3-YL) PYRAZOLO[1,5ALPHA]PYRIMIDINE-3-CARBOXAMID AS INHIBITOR OF ATR KINASE VERTEX PHARMA (US) 2021-04-28 — — EP disclosed
US-10774086-B2 GSK-3 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2020-09-15 — — US disclosed
US-20190276463-A1 GSK-3 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-09-12 — — US disclosed
WO-2019046364-A1 INHIBITORS OF RSV REPLICATION AND APPLICATIONS THEREOF EMORY UNIVERSITY (US) 2019-03-07 — — WO disclosed
US-20090062307-A1 AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS SMITHKLINE BEECHAM CORPORATION (US) 2009-03-05 — — US disclosed
US-20090062307-A1 AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS SMITHKLINE BEECHAM CORPORATION (US) 2009-03-05 — — US disclosed
US-7459454-B2 Aminopyrazine derivatives and compositions SMITHKLINE BEECHAM CORPORATION (US) 2008-12-02 — — US disclosed
US-7459454-B2 Aminopyrazine derivatives and compositions SMITHKLINE BEECHAM CORPORATION (US) 2008-12-02 — — US disclosed
WO-2008071937-A1 NOVEL FLUORESCENT KINASE LIGANDS AND ASSAYS EMPLOYING THE SAME GLAXO GROUP LTD. (GB) 2008-06-19 — — WO disclosed
WO-2008056150-A1 HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY ASTRAZENECA AB (SE) 2008-05-15 — — WO disclosed
EP-0589914-A1 NOVEL 3-FUSED PYRIDINIUMMETHYL CEPHALOSPORINS CHEIL FOODS & CHEMICALS, INC. (KR) 1994-04-06 — — EP disclosed
US-5281589-A Pharmaceuticals CHEIL FOODS & CHEMICALS, INC. (KR) 1994-01-25 — — US disclosed
CN-1078970-A New 3-fused pyridiniummethyl cephalosporins CHEIL FOODS & CHEM (KR) 1993-12-01 — — CN disclosed
WO-1992022556-A1 NOVEL 3-FUSED PYRIDINIUMMETHYL CEPHALOSPORINS CHEIL FOODS & CHEMICALS, INC. (KR) 1992-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090062307-A1 AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS STK25, ABL1, STK35 AOC1 2988/4885AOC3 3520/4885GAA 2194/4885
US-20190276463-A1 GSK-3 INHIBITORS GSK3B, GSK3A, GSKIP AOC1 4866/4885AOC3 3685/4885GAA 963/4885
US-10774086-B2 GSK-3 inhibitors GSK3B, GSK3A, GSKIP AOC1 4866/4885AOC3 3685/4885GAA 963/4885
US-20230105212-A1 BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF CYP51A1, TMBIM6, CYP46A1 AOC1 1984/4885AOC3 3807/4885GAA 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.