Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743424 | 0.85 | ATM (0.58) | ALDH1A1GAAMAPTATMNPSR1 | |
| SCHEMBL16610101 | 0.84 | GAA (0.66) | ALDH1A1GAAMAPTATMHSD17B10 | |
| SCHEMBL1286082 | 0.81 | GAA (0.62) | ALDH1A1GAAMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL20824968 | 0.81 | ALDH1A1 (0.62) | ALDH1A1GAAMAPTATMNPSR1 | |
| SCHEMBL8288448 | 0.81 | ALDH1A1 (0.62) | ALDH1A1GAAMAPTATMNPSR1 | |
| SCHEMBL25094969 | 0.81 | ALDH1A1 (0.67) | ALDH1A1GAAMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL2695688 | 0.81 | ALDH1A1 (0.62) | ALDH1A1GAAMAPTATMNPSR1 | |
| SCHEMBL1812216 | 0.81 | ALDH1A1 (0.62) | ALDH1A1GAAMAPTATMNPSR1 | |
| SCHEMBL11704793 | 0.80 | NAMPT (0.56) | ALDH1A1MAPTSMN1; SMN2NAMPTHTT | |
| SCHEMBL2636120 | 0.80 | GAA (0.66) | ALDH1A1GAAMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328251-B1 | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | ICI PLC (GB) | 1994-04-13 | — | — | EP | disclosed |
| US-4999377-A | 2-(2-hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide compounds; dietetics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-03-12 | — | — | US | disclosed |
| EP-0386920-A2 | 2-Hydroxy-3-thienyloxypropylamino derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-09-12 | — | — | EP | disclosed |
| CN-1034918-A | Chemical compound | ICI PLC (GB) | 1989-08-23 | — | — | CN | disclosed |
| EP-0328251-A2 | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-08-16 | — | — | EP | disclosed |