Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303920 | 0.83 | TSHR (0.46) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL9303062 | 0.83 | TSHR (0.46) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL9302811 | 0.83 | TSHR (0.46) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL27753438 | 0.81 | TSHR (0.55) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL2795354 | 0.81 | TSHR (0.47) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL28019893 | 0.79 | TSHR (0.49) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL30181512 | 0.79 | TSHR (0.49) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL29550542 | 0.79 | TSHR (0.63) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL10714314 | 0.79 | TSHR (0.56) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL34661 | 0.79 | TSHR (0.63) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452212-B1 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | BAUSCH & LOMB (US) | 2015-03-25 | — | — | EP | disclosed |
| US-8827447-B2 | Mono ethylenically unsaturated polymerizable group containing polycarbosiloxane monomers | BAUSCH & LOMB INCORPORATED (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130197125-A1 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | BAUSCH & LOMB INCORPORATED (US) | 2013-08-01 | — | — | US | disclosed |
| US-8420711-B2 | Mono ethylenically unsaturated polymerizable group containing polycarbosiloxane monomers | BAUSCH & LOMB INCORPORATED (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2452212-A2 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | Bausch & Lomb Incorporated (US) | 2012-05-16 | — | — | EP | disclosed |
| US-7994356-B2 | Mono ethylenically unsaturated polycarbosiloxane monomers | BAUSCH & LOMB INCORPORATED (US) | 2011-08-09 | — | — | US | disclosed |
| US-7915323-B2 | Mono ethylenically unsaturated polycarbosiloxane monomers | BAUSCH & LAMB INCORPORATED (US) | 2011-03-29 | — | — | US | disclosed |
| US-20110009587-A1 | MONO ETHYLENICALLY UNSATURATED POLYCARBOSILOXANE MONOMERS | ORAPHARMA, INC. | 2011-01-13 | — | — | US | disclosed |
| US-20110009658-A1 | Mono Ethylenically Unsaturated Polycarbosiloxane Monomers | BAUSCH HEALTH AMERICAS, INC. | 2011-01-13 | — | — | US | disclosed |
| US-20110009519-A1 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | SOLTA MEDICAL, INC. | 2011-01-13 | — | — | US | disclosed |
| WO-2011005937-A2 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | BAUSCH & LOMB INCORPORATED (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009658-A1 | Mono Ethylenically Unsaturated Polycarbosiloxane Monomers | ALOX5, ALOX12, ELOVL5 | TSHR 4814/4885HPGD 123/4885ALDH1A1 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.