Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.58 |
| ▸ | MAOB | P27338 | 8/20 | 0.58 |
| ▸ | TGM2 | P21980 | 5/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PRKCB | P05771 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17154435 | 0.80 | KDM1A (0.51) | MAOAMAOBALDH1A1KDM4EMEN1 | |
| SCHEMBL27369690 | 0.77 | EGFR (0.68) | MAOAMAOBAPPCHEK1ALDH1A1 | |
| SCHEMBL29111180 | 0.75 | TGM2 (0.56) | MAOAMAOBTGM2CES1ALDH1A1 | |
| SCHEMBL28383053 | 0.75 | TGM2 (0.56) | MAOAMAOBTGM2CES1ALDH1A1 | |
| SCHEMBL2789935 | 0.74 | MAOA (1.00) | MAOAMAOBTGM2CES1ALDH1A1 | |
| SCHEMBL27591208 | 0.73 | PDPK1 (0.59) | MAOAMAOBTGM2CES1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10772129 | 0.73 | MAOB (0.65) | MAOAMAOBTGM2CES1ALDH1A1 | |
| SCHEMBL9543511 | 0.73 | APP (0.59) | MAOAAPPALDH1A1MEN1LMNA | |
| SCHEMBL5529117 | 0.72 | GSK3B (0.60) | MAOATGM2CES1ALDH1A1MEN1 | |
| Isatin SCHEMBL28365971 | 0.72 | MAOA (0.95) | MAOAMAOBTGM2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369344-B1 | N-arylation of isatins | ABBOTT LAB (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5151518-A | N-arylation of isatins | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |
| EP-0369344-A1 | N-arylation of isatins | ABBOTT LABORATORIES (US) | 1990-05-23 | — | — | EP | disclosed |