Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 5/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501236 | 0.79 | CA2 (0.48) | PTGS1GAACA1CA2LMNA | |
| SCHEMBL23406145 | 0.75 | HTT (0.42) | GAALMNARECQLMITFS1PR4 | |
| SCHEMBL9558728 | 0.75 | KMT2A (0.61) | GAAHPGDALDH1A1KMT2A | |
| SCHEMBL4145722 | 0.75 | GAA (0.59) | VCAM1PTGS1GAACA1CA2 | |
| SCHEMBL490767 | 0.74 | GAA (0.67) | VCAM1PTGS1GAACA1CA2 | |
| SCHEMBL11674456 | 0.73 | GAA (0.48) | VCAM1PTGS1GAACA1CA2 | |
| Methane SCHEMBL9226524 | 0.73 | GAA (0.65) | VCAM1PTGS1GAACA1CA2 | |
| SCHEMBL9774992 | 0.73 | PTGS1 (0.57) | VCAM1PTGS1GAACA1CA2 | |
| SCHEMBL7647695 | 0.73 | GAA (0.65) | VCAM1PTGS1GAACA1CA2 | |
| SCHEMBL10756626 | 0.73 | GAA (0.56) | VCAM1PTGS1GAALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5002967-A | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1991-03-26 | — | — | US | disclosed |