Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.53 |
| ▸ | GGPS1 | O95749 | 9/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.50 |
| ▸ | FDPS | P14324 | 10/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487200 | 1.00 | S1PR2 (0.53) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL28686742 | 1.00 | S1PR2 (0.53) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL9816412 | 0.98 | FDPS (0.50) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL6831213 | 0.90 | MMP1 (0.52) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL10702679 | 0.88 | LPAR3 (0.51) | GGPS1LPAR3LPAR2LPAR1 | |
| Methane SCHEMBL10785921 | 0.88 | MMP1 (0.50) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL5583954 | 0.87 | S1PR2 (0.37) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL10995960 | 0.81 | S1PR2 (0.53) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| Methane SCHEMBL11500817 | 0.79 | S1PR2 (0.52) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| Phosphoric Acid SCHEMBL23045202 | 0.78 | S1PR2 (0.55) | S1PR2S1PR1S1PR3S1PR5GGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210177893-A1 | Composition and method for treating and healing Medication-Related Osteonecrosis of the Jaw (MRONJ) | LIN CHUN NAN (US) | 2021-06-17 | — | — | US | disclosed |
| WO-2019038420-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOCLAST DISEASES | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-02-28 | — | — | WO | disclosed |
| US-8772267-B2 | Treatment of spinal mechanical pain | NEW YORK UNIVERSITY (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140178499-A1 | COMPOSITION FOR PREVENTING AND HEALING OSTEONECROSIS OF THE JAW | MICROPURE, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-8697141-B2 | Method and composition for preventing and healing osteonecrosis of the jaw | MICROPURE, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110098252-A1 | Treatment of Spinal Mechanical Pain | NEW YORK UNIVERSITY (US) | 2011-04-28 | — | — | US | disclosed |
| US-7875597-B2 | Intravenously administering a bisphosphonate | NEW YORK UNIVERSITY | 2011-01-25 | — | — | US | disclosed |
| US-20100074970-A1 | METHOD AND COMPOSITION FOR PREVENTING AND HEALING OSTEONECROSIS OF THE JAW | MICROPURE, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20070105822-A1 | Novel uses of known drugs | SEWELL ANDREW | 2007-05-10 | — | — | US | disclosed |
| WO-2005053681-A2 | NOVEL USES OF MEVALONATE PATHWAY BLOCKERS | ISIS INNOVATION LIMITED (GB) | 2005-06-16 | — | — | WO | disclosed |
| US-20040087551-A1 | Treatment of spinal mechanical pain | NEW YORK UNIVERSITY | 2004-05-06 | — | — | US | disclosed |