Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.82 |
| ▸ | HPGD | P15428 | 7/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.82 |
| ▸ | CA12 | O43570 | 1/20 | 0.82 |
| ▸ | CA1 | P00915 | 1/20 | 0.82 |
| ▸ | CA2 | P00918 | 1/20 | 0.82 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.82 |
| ▸ | CA4 | P22748 | 1/20 | 0.82 |
| ▸ | CA6 | P23280 | 1/20 | 0.82 |
| ▸ | CA7 | P43166 | 1/20 | 0.82 |
| ▸ | CA9 | Q16790 | 1/20 | 0.82 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.82 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29362663 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29360246 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29606432 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1509155 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1967 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL17156443 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8433746 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8509006 | 0.89 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL1162068 | 0.88 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5183939 | 0.88 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428612-A | Retarder mixture for alkali activation adhesive | 海德堡水泥公司 | 2017-12-01 | — | — | CN | claimed |
| CN-107074650-A | Clinker substitute material made from aluminosilicates and dolomite | 海德堡水泥公司 | 2017-08-18 | — | — | CN | claimed |
| WO-2023196720-A2 | LRRK2 INHIBITORS | Brenig Therapeutics, Inc. (US) | 2023-10-12 | — | — | WO | disclosed |
| EP-3641835-A1 | CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts (DE) | 2020-04-29 | — | — | EP | disclosed |
| CN-104045552-B | Medicinal compound as neuroprotective agent | 江苏先声药业有限公司 | 2019-06-11 | — | — | CN | disclosed |
| WO-2018234236-A1 | CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING | GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS (DE) | 2018-12-27 | — | — | WO | disclosed |
| CN-103857440-B | Antimycotic and antibacterium prodrug based on conjugate | 维奥姆生物科学有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-107649179-A | A kind of preparation method of photocatalysis water oxidation catalyst | 江苏大学 | 2018-02-02 | — | — | CN | disclosed |
| CN-107074650-A | Clinker substitute material made from aluminosilicates and dolomite | 海德堡水泥公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-105859708-A | Salts of dihydropyrimidine derivative and application thereof in medicines | 广东东阳光药业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-104045552-A | Medicinal compound as neuroprotective agent | SHANGHAI SIMCERE PHARMACEUTICAL RES CO LTD | 2014-09-17 | — | — | CN | disclosed |
| WO-2014093626-A1 | COMPOSITIONS AND METHODS FOR HERBICIDE RESISTANCE | Calysta Energy, Inc. (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2010130708-A9 | BETA-LACTAMASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-01-13 | — | — | WO | disclosed |
| US-4738953-A | ETHER-SUBSTITUTED MONOSACCHARIDE AND COMPATIBLE DRUG | GREENWICH PHARMACEUTICALS INCORPORATED (US) | 1988-04-19 | — | — | US | disclosed |
| US-4735934-A | WITH REACTION PRODUCT OF MONOSACCHARIDE AND AMINE | GREENWICH PHARMACEUTICALS INCORPORATED (US) | 1988-04-05 | — | — | US | disclosed |