Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.53 |
| ▸ | GRPR | P30550 | 2/20 | 0.50 |
| ▸ | IL1RN | P18510 | 11/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 10/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9331072 | 0.94 | REN (0.54) | RENGRPRIL1RNERAP2ERAP1 | |
| SCHEMBL9879558 | 0.93 | REN (0.51) | RENGRPRIL1RNERAP2ERAP1 | |
| SCHEMBL9878964 | 0.93 | REN (0.51) | RENGRPRIL1RNERAP2ERAP1 | |
| SCHEMBL9331664 | 0.92 | MMP2 (0.53) | RENGRPRMMP2MMP9MMP8 | |
| SCHEMBL9331193 | 0.91 | REN (0.55) | RENGRPRERAP2ERAP1CTSB | |
| SCHEMBL9334625 | 0.86 | MMP2 (0.55) | RENGRPRMMP2MMP9MMP8 | |
| SCHEMBL9879381 | 0.84 | MMP2 (0.51) | RENGRPRCTSBCTSKMMP2 | |
| SCHEMBL10005187 | 0.83 | GRPR (0.53) | GRPRIL1RNERAP2ERAP1CTSB | |
| SCHEMBL11228026 | 0.82 | TACR1 (0.56) | RENCTSK | |
| SCHEMBL11228028 | 0.82 | TACR1 (0.56) | RENCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315367-B1 | Polypeptides | ICI PLC (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5068222-A | Polypeptides for treatment of cancer | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-11-26 | — | — | US | disclosed |
| EP-0315367-A2 | Polypeptides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-10 | — | — | EP | disclosed |