Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385687 | 0.83 | MAPT (0.46) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9339006 | 0.81 | MAPT (0.44) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9338940 | 0.80 | MAPT (0.42) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9389077 | 0.79 | MAPT (0.48) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9337154 | 0.79 | IRAK4 (0.45) | MAPTNPC1RAB9ALMNAHTT | |
| SCHEMBL9388341 | 0.78 | MAPT (0.41) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9335960 | 0.77 | DYRK1A (0.40) | MAPTNPC1RAB9ADYRK1ALMNA | |
| SCHEMBL9335203 | 0.73 | UNG (0.40) | MAPTNPC1RAB9AUNGHTT | |
| SCHEMBL9335506 | 0.73 | ALDH1A1 (0.39) | MAPTNPC1RAB9ADYRK1AUNG | |
| SCHEMBL9387728 | 0.73 | HSD17B10 (0.43) | MAPTNPC1RAB9ADYRK1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |