Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TNF | P01375 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337065 | 0.86 | PFKFB3 (0.47) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9385687 | 0.86 | MAPT (0.46) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9339038 | 0.83 | ALDH1A1 (0.50) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL9339138 | 0.83 | AHR (0.45) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL9339006 | 0.80 | MAPT (0.44) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL9335960 | 0.79 | DYRK1A (0.40) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9335000 | 0.79 | MAPT (0.41) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9388341 | 0.78 | MAPT (0.41) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9338940 | 0.78 | MAPT (0.42) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL9337154 | 0.77 | IRAK4 (0.45) | MAPTKMT2AMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |