Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335106 | 0.80 | HDAC6 (0.41) | HSD17B10HDAC6AKR1B1AKR1A1PTGER4 | |
| SCHEMBL9339227 | 0.80 | PTGER4 (0.58) | PTGER4HTTCYSLTR1PTGS1PTGS2 | |
| SCHEMBL9335448 | 0.79 | CYP4F2 (0.50) | HDAC6PTGER4DYRK1AHPGDHTT | |
| SCHEMBL9335004 | 0.78 | HSD17B10 (0.39) | HSD17B10HDAC6AKR1B1AKR1A1PTGER4 | |
| SCHEMBL9339297 | 0.78 | NPC1 (0.50) | HSD17B10HDAC6AKR1B1AKR1A1PTGER4 | |
| SCHEMBL9335490 | 0.77 | RAB9A (0.50) | HSD17B10TRPV1DYRK1AALDH1A1HPGD | |
| SCHEMBL28984552 | 0.75 | HDAC6 (0.55) | HDAC6AKR1B1AKR1A1PTGER4DYRK1A | |
| SCHEMBL27399288 | 0.74 | NPC1 (0.43) | HDAC6AKR1B1AKR1A1PTGER4DYRK1A | |
| SCHEMBL9338937 | 0.73 | KAT8 (0.50) | HSD17B10DYRK1AALDH1A1HTTPTGES | |
| SCHEMBL9338942 | 0.73 | KAT8 (0.50) | HSD17B10DYRK1AALDH1A1HTTPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |