Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335232 | 0.88 | HDAC6 (0.38) | HDAC6AKR1B1PTGER4AKR1A1ALOX5 | |
| SCHEMBL9335092 | 0.80 | HSD17B10 (0.43) | HDAC6AKR1B1HSD17B10PTGER4AKR1A1 | |
| SCHEMBL9339227 | 0.76 | PTGER4 (0.58) | PTGER4ALOX5NPC1RAB9AMAPT | |
| SCHEMBL9335004 | 0.74 | HSD17B10 (0.39) | HDAC6AKR1B1HSD17B10PTGER4AKR1A1 | |
| SCHEMBL9339297 | 0.74 | NPC1 (0.50) | HDAC6AKR1B1HSD17B10PTGER4AKR1A1 | |
| SCHEMBL28984552 | 0.74 | HDAC6 (0.55) | HDAC6AKR1B1PTGER4AKR1A1NPC1 | |
| SCHEMBL9335490 | 0.73 | RAB9A (0.50) | HSD17B10TRPV1NPC1RAB9AMAPT | |
| SCHEMBL9338940 | 0.72 | MAPT (0.42) | HDAC6HSD17B10PTGER4TRPV1NPC1 | |
| SCHEMBL7541753 | 0.71 | DYRK1A (0.56) | HDAC6AKR1B1AKR1A1TRPV1ALOX5 | |
| SCHEMBL9338937 | 0.70 | KAT8 (0.50) | HSD17B10ALOX5EPHX2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |