Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.63 |
| ▸ | THRA | P10827 | 6/20 | 0.56 |
| ▸ | THRB | P10828 | 6/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 4/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335675 | 1.00 | HSD17B3 (0.63) | HSD17B3THRATHRBS1PR5HTR7 | |
| SCHEMBL8114139 | 0.98 | HSD17B3 (0.62) | HSD17B3THRATHRBS1PR5HTR7 | |
| SCHEMBL8959879 | 0.93 | HSD17B3 (0.61) | HSD17B3THRATHRBHTR7STS | |
| SCHEMBL28655370 | 0.88 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS | |
| SCHEMBL8083048 | 0.86 | HSD17B3 (0.58) | HSD17B3THRATHRBHTR7STS | |
| SCHEMBL13191872 | 0.84 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS | |
| SCHEMBL13191870 | 0.84 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS | |
| SCHEMBL13191876 | 0.84 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS | |
| SCHEMBL13191875 | 0.84 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS | |
| SCHEMBL13191869 | 0.84 | HSD17B3 (0.59) | HSD17B3THRATHRBS1PR5STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603278-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5312829-A | Testosterone 5alpha-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-17 | — | — | US | disclosed |
| US-5212320-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| WO-1993005019-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-18 | — | — | WO | disclosed |