Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089557 | 0.90 | PTGS1 (0.53) | L3MBTL1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL8959879 | 0.89 | HSD17B3 (0.61) | HSD17B3L3MBTL1THRATHRBSTS | |
| SCHEMBL8114139 | 0.88 | HSD17B3 (0.62) | HSD17B3THRATHRBSTSHTR7 | |
| SCHEMBL9335675 | 0.86 | HSD17B3 (0.63) | HSD17B3THRATHRBSTSHTR7 | |
| SCHEMBL9335705 | 0.86 | HSD17B3 (0.63) | HSD17B3THRATHRBSTSHTR7 | |
| SCHEMBL14297902 | 0.85 | BLM (0.55) | L3MBTL1HPGDSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL9441163 | 0.85 | TRPA1 (0.53) | HPGDSMN1; SMN2PTGS1PTGS2LMNA | |
| SCHEMBL2140146 | 0.85 | PTGS1 (0.52) | L3MBTL1HPGDSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL3526490 | 0.84 | USP5 (0.64) | L3MBTL1SMN1; SMN2PTGS1PTGS2LMNA | |
| SCHEMBL9394922 | 0.84 | FAAH (0.51) | HPGDSMN1; SMN2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519353-B1 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-08-16 | — | — | EP | disclosed |
| JP-2000026344-A | PRODUCTION OF OPTICALLY ACTIVE 1-(4-ISOBUTYLPHENYL)BUTAN-1- OL | NOYORI RYOJI | 2000-01-25 | — | — | JP | disclosed |
| US-5530019-A | FOR TREATMENT OF PROSTATE GLAND DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994018168-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-18 | — | — | WO | disclosed |
| US-5334716-A | Preventing testosteron 5a-reductase mediated diseases; alopecia, acne, prostatism | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0603278-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5312829-A | Testosterone 5alpha-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-17 | — | — | US | disclosed |
| US-5212320-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| WO-1993005019-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-18 | — | — | WO | disclosed |
| EP-0519353-A2 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |
| US-4713485-A | A, A-DIHALOGENATED KETONES HEATED UNDER PRESSURE WITH AQUEOUS ALKALINE METAL HYDROXIDE AND NON-POLAR HYDROCARBON SOLVENTS | SANOFI and Industria Chimica Prodotti FRANCIS S.p.A. (FR) | 1987-12-15 | — | — | US | disclosed |
| US-4675419-A | Process for preparing α-hydroxy-acids and compounds obtained by this process | SANOFI (FR) | 1987-06-23 | — | — | US | disclosed |