Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762886 | 0.85 | HSD17B10 (0.72) | HSD17B10THRBHTTTDP1KDM4E | |
| SCHEMBL9333280 | 0.85 | ALOX15 (0.62) | THRBKDM4EALDH1A1ALOX15MEN1 | |
| SCHEMBL7505146 | 0.84 | HSD17B10 (0.59) | HSD17B10THRBHTTTDP1KDM4E | |
| SCHEMBL7876035 | 0.81 | ALOX15 (0.48) | HSD17B10THRBALOX15MEN1KMT2A | |
| SCHEMBL4446308 | 0.81 | MRGPRX4 (0.58) | HSD17B10THRBSMN1; SMN2PKM | |
| SCHEMBL9524668 | 0.81 | HSD17B10 (0.55) | HSD17B10HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL540767 | 0.81 | MAPK1 (0.67) | HSD17B10HTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13243754 | 0.78 | HSD17B10 (0.65) | HSD17B10THRBHTTTDP1KDM4E | |
| SCHEMBL1356522 | 0.77 | HSD17B10 (0.64) | HSD17B10THRBHTTTDP1KDM4E | |
| SCHEMBL12135360 | 0.77 | HSD17B10 (0.64) | HSD17B10THRBHTTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358953-A | For treatment of allergic rhinitis | PFIZER INC. (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0572425-B1 | IMIDAZOPYRIDINE PAF/H 1 ANTAGONISTS | PFIZER LTD (GB) | 1994-08-03 | — | — | EP | disclosed |
| EP-0572425-A1 | IMIDAZOPYRIDINE PAF/H 1? ANTAGONISTS. | PFIZER LTD (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014734-A1 | IMIDAZOPYRIDINE PAF/H1 ANTAGONISTS | PFIZER LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |