Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 5/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.54 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.54 |
| ▸ | ABAT | P80404 | 1/20 | 0.54 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935705 | 0.85 | MAPT (0.74) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL23407464 | 0.84 | CYP3A4 (0.49) | MAPTGLO1ABL1ALDH1A1TDP1 | |
| SCHEMBL934462 | 0.82 | MAPT (0.62) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL16307895 | 0.82 | MAPT (0.74) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL2213640 | 0.80 | MAPT (0.77) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL7523992 | 0.80 | MAPT (1.00) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL934307 | 0.80 | MAPT (0.70) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL29799957 | 0.80 | MAPT (0.70) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL168150 | 0.80 | MAPT (0.67) | MAPTGLO1ABL1IKBKBCHUK | |
| SCHEMBL29601206 | 0.80 | MAPT (0.67) | MAPTGLO1ABL1IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006566-A2 | MONOMETHOXY-HYDROXY-BENZYLMALONATES | MERCK PATENT GMBH (DE) | 2011-01-20 | — | — | WO | disclosed |