Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 11/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8731379 | 0.85 | LTB4R (0.70) | LTB4RMRGPRX4PLA2G4BPTPN11 | |
| SCHEMBL8862137 | 0.84 | LTB4R (0.74) | LTB4RPLA2G4B | |
| SCHEMBL9333856 | 0.78 | LTB4R (0.49) | LTB4RMRGPRX4PLA2G4BPTPN11 | |
| SCHEMBL8732073 | 0.73 | LTB4R (0.74) | LTB4R | |
| SCHEMBL8734202 | 0.71 | LTB4R (0.64) | LTB4RPTPN11 | |
| SCHEMBL9367967 | 0.70 | LTB4R (0.64) | LTB4R | |
| SCHEMBL9333801 | 0.70 | LTB4R (0.58) | LTB4RMRGPRX4TP53PKMNFKB1 | |
| SCHEMBL9333838 | 0.70 | LTB4R (0.64) | LTB4R | |
| SCHEMBL9337179 | 0.69 | LTB4R (0.69) | LTB4R | |
| SCHEMBL9334167 | 0.69 | LTB4R (0.66) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604529-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0593464-A1 | BENZOIC ACID DERIVATIVES and their use as LTB4 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993006085-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0593464-A4 | BENZOIC ACID DERIVATIVES. | SMITHKLINE BEECHAM CORP (US) | 1993-02-12 | — | — | EP | disclosed |
| WO-1991018601-A1 | BENZOIC ACID DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |