Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 17/20 | 0.70 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732073 | 0.86 | LTB4R (0.74) | LTB4R | |
| SCHEMBL9336789 | 0.85 | LTB4R (0.52) | LTB4RPLA2G4BPTPN11MRGPRX4 | |
| SCHEMBL8734202 | 0.85 | LTB4R (0.64) | LTB4RPTPN11 | |
| SCHEMBL9367967 | 0.84 | LTB4R (0.64) | LTB4R | |
| SCHEMBL9333801 | 0.83 | LTB4R (0.58) | LTB4RMRGPRX4 | |
| SCHEMBL9333838 | 0.83 | LTB4R (0.64) | LTB4R | |
| SCHEMBL8075772 | 0.82 | LTB4R (1.00) | LTB4R | |
| SCHEMBL27351072 | 0.82 | LTB4R (1.00) | LTB4R | |
| SCHEMBL9333856 | 0.82 | LTB4R (0.49) | LTB4RPLA2G4BPTPN11MRGPRX4 | |
| SCHEMBL9337179 | 0.82 | LTB4R (0.69) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593464-A1 | BENZOIC ACID DERIVATIVES and their use as LTB4 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-27 | — | — | EP | claimed |
| EP-0593464-A4 | BENZOIC ACID DERIVATIVES. | SMITHKLINE BEECHAM CORP (US) | 1993-02-12 | — | — | EP | claimed |
| WO-1991018601-A1 | BENZOIC ACID DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-12 | — | — | WO | claimed |
| EP-0812194-A4 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORP (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0812194-A1 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026725-A1 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-06 | — | — | WO | disclosed |
| EP-0604529-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006085-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |