Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661862 | 0.86 | KDM4E (0.49) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL8222197 | 0.79 | KDM4E (0.45) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL15416243 | 0.78 | KDM4E (0.55) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL7193003 | 0.77 | KDM4E (0.46) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6543889 | 0.77 | ALOX5 (0.44) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL9868223 | 0.77 | KDM4E (0.53) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL30063329 | 0.77 | ALOX5 (0.44) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6157427 | 0.76 | CYP2A6 (0.44) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL11868299 | 0.76 | ALOX5 (0.48) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL8003423 | 0.76 | ALOX5 (0.54) | KDM4EDAOMAPTHPGDSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332755-A | Leukotriene antagonists as antiinflammatory agents and antiallergens | BAYER AKTIENGESELLSCHAFT (DE) | 1994-07-26 | — | — | US | disclosed |
| US-5118700-A | Leukotriene antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1992-06-02 | — | — | US | disclosed |
| EP-0409027-A1 | Indole derivatives, process for their preparation and their use in pharmaceuticals | BAYER AG (DE) | 1991-01-23 | — | — | EP | disclosed |