Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339225 | 0.74 | GPR84 (0.47) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9432494 | 0.73 | KDM4E (0.42) | DAOMAPTCYP1A2CYP3A4GRIN2D | |
| SCHEMBL27772446 | 0.73 | GPR84 (0.46) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL891270 | 0.72 | HIF1A (0.53) | GPR84HIF1AEPAS1DAOMAPT | |
| SCHEMBL15775820 | 0.72 | PARP1 (0.64) | GPR84PARP1MAPTLMNAKMT2A | |
| SCHEMBL1256978 | 0.70 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9228183 | 0.70 | HIF1A (0.54) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9341196 | 0.70 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9340937 | 0.70 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL8114255 | 0.70 | TSHR (0.45) | HIF1APARP1MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |