Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 4/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1256978 | 0.83 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9341196 | 0.83 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9232786 | 0.80 | GPR84 (0.41) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9337108 | 0.80 | ALDH1A1 (0.47) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9337293 | 0.79 | GPR84 (0.44) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9340753 | 0.79 | GPR84 (0.41) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9337505 | 0.78 | GPR84 (0.40) | GPR84HIF1AEPAS1DAOPARP1 | |
| SCHEMBL9339225 | 0.77 | GPR84 (0.47) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9340882 | 0.76 | GPR84 (0.39) | GPR84HIF1AEPAS1DAOTYMP | |
| SCHEMBL9336948 | 0.76 | GPR84 (0.39) | GPR84HIF1AEPAS1DAOTYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |