Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9340199 | 0.91 | ACHE (0.33) | TSHRACHE | |
| SCHEMBL3842819 | 0.85 | ACHE (0.35) | TSHRACHE | |
| SCHEMBL10343591 | 0.81 | MEN1 (0.38) | TSHRACHE | |
| SCHEMBL9339985 | 0.78 | CYP1A2 (0.46) | TSHRCYP3A4HPGDSMN1; SMN2LPAR1 | |
| SCHEMBL9417123 | 0.78 | MEN1 (0.42) | TSHRCYP3A4HPGDSMN1; SMN2LPAR1 | |
| SCHEMBL9337737 | 0.76 | ACHE (0.33) | TSHRACHE | |
| SCHEMBL8971494 | 0.74 | ACHE (0.36) | TSHRACHE | |
| SCHEMBL9062812 | 0.73 | MEN1 (0.42) | TSHRCYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL9336312 | 0.72 | ACHE (0.33) | TSHRACHE | |
| SCHEMBL9063517 | 0.72 | TSHR (0.43) | TSHRCYP3A4ACHEHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319482-B1 | Novel substituted propane phosphinic acid compounds | CIBA GEIGY AG (CH) | 1994-05-18 | — | — | EP | disclosed |
| US-5064819-A | Antidepressants, anxiolytic agents, GABA antagonists | CIBA-GEIGY CORPORATION (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0319479-A2 | Substituted propane-phosphinic acid compounds | CIBA-GEIGY AG (CH) | 1989-06-07 | — | — | EP | disclosed |
| EP-0319482-A2 | Novel substituted propane phosphinic acid compounds | CIBA-GEIGY AG (CH) | 1989-06-07 | — | — | EP | disclosed |