Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27353989 | 0.75 | TSHR (1.00) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL9570719 | 0.73 | TFPI2 (0.41) | TSHRMAPTRAB9ANOTUM | |
| SCHEMBL1023583 | 0.72 | TSHR (0.59) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL1023584 | 0.72 | TSHR (0.59) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL14156261 | 0.71 | POLB (0.86) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL1023299 | 0.71 | TSHR (0.57) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL9050997 | 0.71 | TSHR (0.57) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL9051218 | 0.71 | TSHR (0.51) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL8539574 | 0.70 | TSHR (0.59) | TSHRLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL30489692 | 0.70 | TSHR (0.76) | TSHRLMNAMAPTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5336679-A | Treatment of irritable bowel syndrome | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-08-09 | — | — | US | claimed |
| US-5336679-A | Treatment of irritable bowel syndrome | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-08-09 | — | — | US | disclosed |