Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074193 | 0.81 | NOTUM (0.41) | CNR2 | |
| SCHEMBL7334149 | 0.76 | PTGDR2 (0.44) | MAPTHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL1023584 | 0.72 | TSHR (0.59) | TSHRLMNAMAPK1MAPTHSD17B10 | |
| SCHEMBL1023583 | 0.72 | TSHR (0.59) | TSHRLMNAMAPK1MAPTHSD17B10 | |
| Fumaric Acid SCHEMBL9051209 | 0.71 | TSHR (0.52) | TSHRLMNAMAPK1MAPTHSD17B10 | |
| SCHEMBL9052108 | 0.71 | HTR3A (0.46) | LMNAMAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL9052002 | 0.71 | ALDH1A1 (0.36) | LMNAMAPTHSD17B10RAB9AALDH1A1 | |
| SCHEMBL9338317 | 0.71 | TSHR (0.57) | TSHRLMNAMAPK1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL1023299 | 0.71 | TSHR (0.57) | TSHRLMNAMAPK1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL9050997 | 0.71 | TSHR (0.57) | TSHRLMNAMAPK1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |