Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9336969 | 0.88 | KCNH2 (0.42) | HTTCRHR1TDP1SMN1; SMN2MEN1 | |
| SCHEMBL17604111 | 0.85 | HTT (0.47) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL27398194 | 0.85 | CRHR1 (0.46) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL9335465 | 0.78 | ALDH1A1 (0.47) | HTTALDH1A1TDP1SMN1; SMN2TSHR | |
| SCHEMBL10761854 | 0.76 | SMN1; SMN2 (0.46) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL8996253 | 0.75 | HTT (0.49) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL8996311 | 0.75 | HTT (0.49) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL13675540 | 0.74 | HTT (0.44) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL13675543 | 0.74 | HTT (0.44) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL8996243 | 0.73 | HTT (0.47) | HTTCRHR1ALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0394440-B1 | PHENYLCARBOXYLIC ACID DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 1994-05-11 | — | — | EP | disclosed |
| US-4999378-A | Antilipemic, anticholesterol, antidiabetic, treatment of atherosclerosis and obesity | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-03-12 | — | — | US | disclosed |
| EP-0394440-A1 | PHENYLCARBOXYLIC ACID DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |